PharmFreq

The Pharmacogenetic allele Frequency (PharmFreq) database is a collated repository and search tool for country-specific pharmacogenetic allele frequency at a global scale. It allows users to explore the ethnogeographic variability of genetically encoded drug response differences and identify outlier populations that might benefit from therapeutic adjustments.




Studies
1267
Sample size
>10 Mio.
Countries
144


Pharmacogenes
21
Alleles
658
App. affected drugs
150


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Click on a row to load the individual raw data per country or region. All data can be downloaded by clicking the download button located at the bottom of the page.

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High-risk genotype frequency

This tool can be used to estimate the proportion of individuals in a population or country harboring high-risk genomic variants for selected pharmacogenes with established guidelines. To resize the plot, simply click and drag the bottom-right corner using your mouse.








Frequency comparison

With this tool, allele frequencies can be compared between ethnogeographic subgroups. Different regions, one gene, and corresponding multiple alleles can be selected. The allele frequencies are summarized and displayed for each country. A boxplot visually represents the distribution of allele frequencies across selected regions, providing a clear comparison of variations between populations. All data can be downloaded by clicking the download button located at the bottom of the page. To resize the plot, simply click and drag the bottom-right corner using your mouse.







Intra-biogeographic variability

This analysis examines both intra- and interindividual differences in allele frequencies among ethnogeographic subgroups. Furthermore, it highlights the frequency differences present within the selected subgroups, providing a detailed comparison of genetic variation across different populations. All data can be downloaded by clicking the download button located at the bottom of the page. To resize the plot, simply click and drag the bottom-right corner using your mouse.







Country data tool

With this tool, you can download all available allele frequency data for a selected gene and country or ethnic subgroups. Multiple countries/subgroups can be selected simultaneously. When several studies were available, the data was summarized by the median or wighted median (defualt selection). To download all data, please use the button located below the table




Metabolizer status tool

This tool is designed to calculate the frequency of phenotypes (PM = Poor Metabolizer, IM = Intermediate Metabolizer, NM = Normal Metabolizer, UM = Ultra-rapid Metabolizer) for pharmacogenes according to established guidelines. Countries are not listed in the selection when too many key alleles for the phenotypes are missing. Furthermore, certain variants of a single phenotype may be missing, leading to incomplete results.




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Study finder

Looking for a specific study in the database? Search here to see which studies and data are included in PharmFreq.




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Frequently Asked Questions




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